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08-18

2023

All relevant units: Diet is better for metabolic health and anti-aging

Modifying diet may be more effective than taking drugs at controlling conditions such as diabetes, stroke and heart disease, according to an Australian preclinical study. The study showed that nutrition, including total calories and macronutrient balance, has a greater impact on aging and metabolic health than the three commonly used diabetes and anti-aging drugs. The results were published in Cell Metabolism. The study builds on the team's pioneering work in mice and humans, demonstrating the protective effects of diet and specific combinations of protein, fat, and carbohydrates on the risk of aging, obesity, heart disease, immune dysfunction, and metabolic diseases such as type 2 diabetes. There has been an ongoing effort to find drugs that improve metabolic health and aging without changing diet. "Diet is good medicine. However, drugs are currently administered without considering whether and how they can interact with dietary components - even though these drugs act in the same way and nutritional signaling pathways as diet." Professor Stephen Simpson, corresponding author of the paper and academic director of the Charles Perkins Centre at the University of Sydney. So the researchers set out to see whether drugs or diets were more effective at reshaping nutrient perception and other metabolic pathways, and whether interactions between drugs and diets made them more effective. The team designed a complex mouse study that included 40 different approaches, each with different amounts of protein, fat and carbohydrates, calories and drugs. The study was designed to examine the effects of three anti-aging drugs on the liver, a key organ that regulates metabolism. A key strength of the study is the use of a nutritional geometric framework developed by Simpson and colleague David Raubenheimer. This framework allows researchers to consider how mixtures and interactions of different nutrients affect health and disease, rather than focusing on any one nutrient in isolation - a limitation of other nutrition studies. "We found that diet has a much stronger effect than drugs. Drugs largely suppress people's responses to diet rather than reshape them." "Given that humans and mice essentially share the same nutritional signaling pathways, the study suggests that people who change their diet to improve their metabolic health may have better results than if they were taking a drug," Simpson said. The findings help to understand the mechanisms between what we eat and how we age. Studies have found that calorie intake and the balance of macronutrients (protein, fat, and carbohydrates) in the diet have a big impact on the liver. Protein and total calorie intake have a particularly large impact on metabolic pathways and the basic processes that control cell function. For example, the amount of protein consumed affects the activity of the mitochondria, the part of the cell that produces energy. This creates a downstream effect, as the intake of protein and dietary energy affects the accuracy with which cells convert their genes into different proteins (which help cells function properly and make new cells), both of which are fundamental processes involved in aging. Drugs, by contrast, work primarily by inhibiting the cells' metabolic response to diet, rather than fundamentally reshaping them. However, the researchers also found some more specific interactions between the biochemical effects of drugs and dietary components. One anti-aging drug had a greater effect on cellular changes caused by dietary fats and carbohydrates, while a cancer drug and another diabetes drug both blocked the effects of dietary proteins on energy-producing mitochondria. David Le Couteur, one of the authors of the paper and a professor at the Charles Perkins Center, said that although the study is very complex, it shows how important it is to look at many different diets at once, rather than just comparing several different diets. "We all know that what we eat affects health, but this study shows that food can significantly affect many processes in the cells of the human body." This gives us insight into how diet affects health and aging."

07-04

2023

Chen Xiaoqing, director of Guangming District Science and Technology Innovation Bureau, visited Zhongke Arno Biological research and guidance

Director Chen Xiaoqing and his delegation made a comprehensive inspection of Guangming District's largest tonnage synthetic biological reactor platform, clean workshop and industry-university-research integration technology research laboratory, systematically understood and investigated the situation from research and development to production, and fully affirmed and highly praised the synthetic biology technology of ZhongKearnau, as well as the construction speed, industrialization speed of scientific and technological achievements and technological innovation of ZhongKearnau.

06-14

2023

Chen Yang, chairman of Zhongke Arnault (Shenzhen) Biotechnology Co., Ltd. accepted a special interview with Bright Financial Media and English "Shenzhen Daily"

Chen Yang, chairman of Zhongke Arnault (Shenzhen) Biotechnology Co., Ltd. accepted a special interview with Bright Financial Media and English "Shenzhen Daily" "Guangming Science City is the pioneering area of the comprehensive National Science Center in the Greater Bay Area, a gathering place for high-level talents at home and abroad, and an innovation highland of synthetic biology. It attaches great importance to the research of synthetic biology technology and the development of enterprises, and has formulated a series of industrial support policies, which is one of the reasons why she chose Guangming."

05-11

2023

Comrade Wu Zhaoling, deputy director of the Standing Committee of the Guangming District People's Congress, led a delegation of deputies to inspect Zhongke Arnaud Biology

Comrade Wu Zhaoling, deputy director of the Standing Committee of the Guangming District People's Congress, led a delegation of deputies to inspect Zhongke Arnaud Biology Director Wu Zhaoling and his delegation made a comprehensive inspection of the Zhongke Arnault Biological modular flexible intelligent manufacturing plant, including new strains and algae strains cultivation and development room, biorereactor platform, purification and extraction workshop, GMP workshop and industry-universation-research integration technology research laboratory, and conducted in-depth exchanges on how to speed up the construction of Bright Science City.

04-06

2023

Dr. Arnaud Yansheng recently made a special trip to the California Center for Renewable Medicine at the University of California, Berkeley

Dr. Arnau Yansheng recently made a special trip to the California Center for Renewable Medicine at the University of California, Berkeley, USA, to visit Professor Randy Schekman, winner of the 2013 Nobel Prize in Physiology/Medicine and a leading expert in the field of cell biology, and made in-depth exchanges and discussions on innovative research and development cooperation in the transport mechanism of cell membranes and the application of synthetic biotechnology.

07-10

2023

Unique absorption. Nudialga/Nudialga polysaccharide (β-1, 3 glucan)

Unique absorption. Nudialgae/nudialgae polysaccharide (β-1, 3 glucan) is a rare single-celled organism with the dual characteristics of animals and plants. It has no cell wall and only a protein-rich membrane. Compared with spirulina and Chlorella, its free-floating nudialgae polysaccharide is easy to be separated from cells and the micronutrients contained in it are easier to be absorbed. The absorption rate is as high as 93.1%, which has a high nutritional efficiency.

07-10

2023

Nudialgae/nudialgae polysaccharides (β-1, 3-glucan) contain vitamins, mineral nutrients, amino acids, unsaturated fatty acids

Provide total factor nutrition. Nudialgae/nudialgae polysaccharide (β-1,3 glucan) has 59 kinds of nutrients that are important to the human body, such as vitamins, mineral nutrients, amino acids, unsaturated fatty acids, chlorophyll, lutein, etc., especially containing all amino acids required by the human body similar to breast milk. The amino acid content is far better than that of the same type of microalgae, which is 1.53 times that of chlorella. 1.62 times that of spirulina.

07-10

2023

Nudialgae/Nudialgae polysaccharides (β-1, 3-glucan)

Nudialgae/nudialgae polysaccharide (β-1, 3 glucan) : has strong immunity, anti-allergy, antiviral and anti-tumor activities, rich in a variety of vitamins, amino acids and polyunsaturated fatty acids, with high nutritional value.

08-27

2023

Good news Zhongke Arno obtained a new resource food naked algae "Food Production License"

Recently, Zhongke Arnault passed the strict review procedure of Shenzhen Market Supervision Administration, and successfully obtained the "Food production License" of new resources food naked algae, which is highly recognized and affirmed the unremitting efforts and innovation achievements of Zhongke Arnault, which not only marks that Zhongke Arnault has the innovation chain and industrial chain integration ability of naked algae from research and development to industrialization. Moreover, it has also qualified for the production of nude algae as well as the sales and import and export management. Zhongke Arnault has made milestone progress on the road of promoting the commercialization of nude algae.

07-10

2023

ArnoGlenaTM Nudiella/Nudiella polysaccharides (β-1, 3-glucan)

ArnoGlenaTM Nudiella/Nudiella polysaccharides (β-1,3 glucan) : It has been studied and developed by Zhongke Arnaud's experts in the United States for more than ten years. It is derived from the fine Nudiella species under natural conditions, grows heterotrophic in the closed vertical tank under aerobic conditions, and is extracted by natural fermentation without heavy metal pollution, containing more than 70% of β-1,3 glucan, which has higher purity and stronger biological activity than ordinary cultivated nudiella.

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